The Spike infection decreased NAD+-dependent protein deacetylases 3, SIRT3, that maintains mitochondrial metabolic activity (22) (0.59-fold in Spike vs VSV-G, P = 0.0031) (Fig. 4F) and translocase of the outer membrane of mitochondria, TOMM22, gene expression (0.73-fold in Spike vs VSV-G, P = 0.0229) (Fig. 4G). Here, TOMM22 is linked to infection.