ERBB2 and colorectal carcinoma: Furthermore, T-DXd has recently shown solid results with 45.3% of ORR, 6.9 months of PFS, and 15.5 months of OS in the patients with HER2-positive (immunohistochemistry, IHC3+ or IHC2+/in situ hybridization, ISH+) CRC in DESTINY-CRC01 study.