Due to the TAM production of insulin-like growth factor (IGF)-1 (with an elevated IGF-1 mRNA level expressed by BM-derived macrophages), a clodronate-liposome-mediated TAM depletion hindered MM development both in vitro and in vivo by reducing the migration and homing of 5TGM1 MM cells within the BM [88]. The gene discussed is IGF1; the disease is Miyoshi myopathy.