MTHFR and esophageal squamous cell carcinoma: Esophageal squamous cell carcinoma (ESCC) involves genes that encode regulators of numerous cellular processes, such as methylenetetrahydrofolate reductase (MTHFR), cell cycle control—(tumor protein p53 (TP53), Aurora kinase A (AURKA), bone morphogenetic protein-7 (BMP7), and others.