Further PPI network analyses in this study indicated that PODNL1 protein shared similar domain with LRG1 of the LRR family, which has been verified to bind to and interact with the receptors of TGF-β signaling including ACVRL1, ENG and TGFBR1, and is involved in the progression of cancer and inflammatory disorders [40]. This evidence concerns the gene ACVRL1 and cancer.