In some breast cancer models, downregulated SLRPs of classes I and II, e.g., decorin and lumican, are demonstrated to be correlated with tumor-suppressive function [6,7], and in other models, high levels of lumican in non-metastatic pancreatic cancer are found to be associated with a more quiescent cancer cell state and prolonged patient survival [8]. This evidence concerns the gene LUM and breast cancer.