In some breast cancer models, downregulated SLRPs of classes I and II, e.g., decorin and lumican, are demonstrated to be correlated with tumor-suppressive function [6,7], and in other models, high levels of lumican in non-metastatic pancreatic cancer are found to be associated with a more quiescent cancer cell state and prolonged patient survival [8]. The gene discussed is LUM; the disease is cancer.