DEGs between the V group and the SV group were enriched in primary immunodeficiency, natural killer cell-mediated cytotoxicity, NF-κB signaling pathway, B-cell receptor signaling pathway, FcγR-mediated phagocytosis, PI3K-Akt signaling pathway, cytokine-cytokine receptor interaction and TNF signaling pathway (Figure 6). The gene discussed is TNF; the disease is inborn error of immunity.