Amplified demethylases with the highest prevalence, above 10% in basal cancers, included H3K4 demethylases KDM5A from locus 12p13.33 and KDM5B from 1q32.1 and H3K9 demethylase KDM4C from 9p24.1 (Figure 7). The gene discussed is MBD2; the disease is cancer.