mRNA expressions in claudin-low cancers were, for most DNA demethylases, not significantly up-regulated or down-regulated, with mean z-scores of expression between −0.5 and 0.5 except for KDM2B, which was up-regulated (mean z-score 0.87), and KDM4B and KDM5B, which were down-regulated (mean z-scores −1.03 and −0.86, respectively, not shown). The gene discussed is KDM4B; the disease is cancer.