Ten genes are associated with neurologic disorders (green print in Table S3 column J), including the IRF3 gene associated with an encephalopathy (M616532) conferring headaches and brain fog and the RAB7A gene with a form of Charcot–Marie–Tooth disease (M600882) that is associated with 16 EDS-relevant genes. The gene discussed is IRF3; the disease is nervous system disorder.