The shared LIFR leukemia inhibitory factor receptor (M151443) with immunoglobulin/cytokine domains and the NLRP3 (M606416) pyrin-like genes could be involved in the inflammatory response to COVID-19 as well as the enhanced inflammation from adrenergic stimulation in EDS and other conditions [10,11,18,78]. This evidence concerns the gene LIFR and COVID-19.