F2 and Ehlers-Danlos syndrome: Genes highlighted by variance or expression in both disorders include the F2 prothrombin gene (M176930) related to bleeding disorders and the metalloproteases ADAMTS2 (M6045539) and ADAMTS13 (M604134), with the latter gene product interacting with the von Willebrand factor that had 18 coding variants in EDS (Table S2).