The genes associated with EDS (317) or COVID-19 severity (104) are distributed on all chromosomes (except for Y and 8, 13, 16, 20 for COVID-19) with clusters at 2q32.2 (COL5A2/COL3), 3p24.1 (SCN5/10/11A), 11q23.3 (SCN2/4B), and 21q22.3 (COL6A1/A2) for EDS and at 3p22.2 (CCR1/5-CXCR6) for COVID-19 (Tables S2 and S3, column L). Here, VPS45 is linked to COVID-19.