Molecular and clinical qualification appropriately assigns a 4+ diagnostic utility to the COL3A1-FLG variant combination, with the symptom pattern favoring hypermobile EDS even though frequent associations of COL3A1 variants with vascular EDS (M130050) might add screening for aneurysms to its usual management. Here, COL3A1 is linked to Ehlers-Danlos syndrome, vascular type.