POLD4 and Ehlers-Danlos syndrome: The POLG (M174763) and NDUFA11 (M612638) gene variants in EDS are most easily related to neurologic and autonomic symptoms, with a high certainty for the similar POLD4 (M611525) gene (Table S3) and the NDUFAF7 (M615898) gene likely presenting a neurologic impact [41].