Similar dualities for the STAT1 (M600555), TNFRSF13B (M6049097), and TICAM1 (M607601) genes may apply since the first two are associated with immunodeficiency disorders and the last confers susceptibility to encephalopathy from herpes virus infection (Table S3). The gene discussed is TNFRSF13B; the disease is Encephalopathy.