The mitochondrial DNA polymerase gamma (POLG) variants [18] would be related to the developmental disability of patient 4 (Figure 1, last column) based on that disease association (M302700+) and differently related to the dysautonomia symptoms of the 17 EDS patients in Table S2 based on the encephalopathic–gastrointestinal dysmotility symptoms of the other POLG-associated disease (M613662+). The gene discussed is POLG; the disease is Gastrointestinal dysmotility.