Complement components C1q, C4A, C4B, and C2B are the gene loci with the highest risk for developing SLE, followed by genes involved in the IFN-I signaling pathway (IRF5, ITGAM) and genes related to B lymphocyte signaling (BANK1 and BLK). The gene discussed is ITGAM; the disease is systemic lupus erythematosus.