To investigate the involvement of NOX4 protein in thyroid tumor aggressiveness, we observed a statistically significant correlation between the overexpression of NOX4 protein and the presence of a capsular breach, indicating the association of NOX4 protein with the aggressiveness of thyroid carcinomas in our cohort (p-value = 0.0481) (see Table 4). The gene discussed is NOX4; the disease is thyroid gland carcinoma.