Interestingly, some studies observed that mutated MUC16 influence on survival or prognosis in various cancers; Liu et al. [5] found that MUC16 mutations were associated with better overall survival in patients with hepatocellular carcinoma, whereas Wang et al. [50] found that MUC16 mutations were associated with overall survival in patients with melanoma. The gene discussed is MUC16; the disease is melanoma.