Germline mutation inactivation of the tumor suppressor BAP1 in combination with activating BRAF or NRAS mutationSomatic mutations probability of a BRAF mutation is significantly higher in patients younger than 40germline pathogenic mutations in BAP1 gene result in a cancer predisposition syndromehigh-CSD melanoma/lentigo maligna melanoma with BRAFV600K being more frequent than BRAFV600Emutations, mutations of NF1 in 30% and KITincreased mutational frequencies in TP53, and ARID2 and cromosomal aberrationsimmune checkpoint blockade (ICB). The gene discussed is BAP1; the disease is melanoma.