Somatic mutations BRAF and NRAS melanoma driver mutations analysed for NM (nodular melanoma) and SSM (superficial spreading melanoma)Eight genes were found to be statistically mutated: NOTCH4, RPS6KA6, BCL2L12, ERBB3, TERT, SNX31, SSPO, and ZNF560 (all p < 0.05)three Nmspecific SNVs in ANK3, NOTCH4 and ZNF560checkpoint blockade immunotherapy (105 NM, 49 SSM)BRAF-targeted therapy (35 NM, 21 SSM). The gene discussed is RPS6KA6; the disease is melanoma.