Somatic mutations 1 BRAF mutant melanoma (ETH-E)2 NRAS mutant melanomas (SK-G & ETH-J)3 BRAF/NRAS/NF1 wild-type (MI-F, SK-H, ETH-FGain and loss of somatic SNVsBRAF identified(n = 8 patients), FAT4 (n = 6), TP53 (n = 4), KMT2C (n = 4), GRIN2A (n = 6), NRAS (n = 2), WRN (n = 4), and ARID2 (n = 4) amongst the most affected genes. This evidence concerns the gene WRN and melanoma.