SUFU mutations have been described in familial meningioma (OMIM 607174), desmoplastic medulloblastoma (OMIM 155255), and Joubert syndrome-32 (OMIM 617757), the latter of which is a developmental disorder that is characterized by delayed psychomotor development, intellectual disability, dysmorphic facial features, and postaxial polydactyly. Here, SUFU is linked to medulloblastoma.