HMOX1 and gastric ulcer: ZnC reduced dose-dependently pro-inflammatory cytokines such as IL-1β, IL-8, IL-6, and TNF-α in rats affected by gastric ulcers [6]; in such studies, the rats which received ZnC showed concentrations of antioxidants such as SOD-1, SOD-2, heme oxygenase-1 (HO-1), peroxiredoxin-1 (Prx-1), and Prx-5 higher than controls [6].