Recently, S001PR930 and the S1PR1 modulator IMMH1 (SYL4) inhibited the progression of arthritis in Sprague-Dawley rats, as evidenced by reduced hind paw swelling and reduced arthritis index, alongside decreased levels of pro-inflammatory cytokines and chemokines in affected joints [107]. The gene discussed is S1PR1; the disease is arthritic joint disease.