Furthermore, we examined the expression of neuronal markers, such as NeuN and MAP2, which are known to play beneficial roles in anti‐apoptotic processes and neuron survival (Zhang et al., 2015), Additionally, synaptic markers PSD95 and synaptophysin, which are associated with synaptic transmission, synaptic plasticity, and synaptogenesis maintenance (Liu et al., 2010), and LTP related molecules phosphorylated and total GluR1 and CaMKII were assessed by western blotting in 3xTg‐AD mice and APPswe‐transfected HT22 cells. Here, DLG4 is linked to Alzheimer disease.