Collectively, these data suggest that FGF10 exerts its neuroprotective effects by activating the FGFR2/PI3K/AKT pathway as a key mechanism to ameliorate tau hyperphosphorylation and neuronal apoptosis in 3xTg‐AD mice and APPswe‐transfected HT22 cells. Here, AKT1 is linked to Alzheimer disease.