MAPT and Alzheimer disease: However, a growing body of evidence suggests that aberrant accumulation of Aβ, hyperphosphorylation of tau, and apoptosis play pivotal roles in the pathogenesis of AD and have emerged as important targets for AD diagnosis and therapeutic interventions (Behl, 2000; Iqbal et al., 2010; Serrano‐Pozo et al., 2011; Teipel et al., 2022).