Regarding the role of NaR, high concentrations of this metabolite do not inhibit WD by itself (Alexandris et al., 2022; Sasaki et al., 2021) and while NaMN may inhibit purified SARM1 (Sasaki et al., 2021), the NaMN/NMN ratio does not predict SARM1 activity like the NAD+/NMN ratio does in axons (Alexandris et al., 2022). This evidence concerns the gene SARM1 and Wilson disease.