In confirmatory experiments in mice, Sarm1 knock out (KO) was shown to suppress classical WD in a manner similar to WldS (Gerdts et al., 2013; Osterloh et al., 2012), and further work over the last decade characterized the function of SARM1 as a NADase that is required for axon degeneration after injury and whose forced activation is sufficient to induce axonal degeneration in healthy neurons (Gerdts et al., 2015). This evidence concerns the gene SARM1 and Wilson disease.