MFN2 and Charcot-Marie-Tooth disease type 2A1: The idea of SARM1 contributing to chronic neurodegeneration by a feed-forward mechanism centered on mitochondrial pathology has been recently proposed in Charcot-Marie-Tooth disease type 2A caused by mutations in the mitochondrial gene mitofusin 2 (MFN2) (Sato-Yamada et al., 2022).