Furthermore, IFN-γ promotes nuclear translocation and phase separation of Yes-associated protein (YAP) in tumour cells, which mediated adaptive resistance to ICBT by forming transcriptional hubs with TEA domain transcription factor 4 (TEAD4), E1A-associated protein p300 (EP300), and mediator of RNA polymerase II transcription subunit 1 (MED1) to maximise cancer-promoting gene transcription [77]. Here, EP300 is linked to cancer.