High IFN signalling with NK response priming predicted associated with poor survival, while T cell response priming predicted associated with a favourable response (datasets combined from Liu, Gide, and Riaz papers). ISG expression was associated with improved survival in tumors with 6p21.3 disomy. Serum IFNγ and HLA-E expression in non-responders at 6 months posttreatment from 202 ICBT-treated individuals with melanoma. The gene discussed is HLA-E; the disease is melanoma.