In survival analysis of calpain members, we found the higher expression of CAPN7, CAPN11, CAPN5, and CAPNS2 was associated with better OS of HCC and higher expression of CAPN15, CAPN10, CAPN2, CAPN8, and CAPN14 was associated with worse OS of HCC (Figure 3). The gene discussed is CAPN5; the disease is hepatocellular carcinoma.