The calpain family members have numerous substrates, some of which were well-known to promote cancer progression, such as the tumor suppressor P53; signaling molecules PKC and FAK; proto-oncogenes c-fos and c-jun; and apoptosis proteins caspase-3, -7, -8, -9, and -12 (Nian and Ma, 2021). The gene discussed is TP53; the disease is cancer.