After analyzing the expression distribution of high- and low-risk calpain groups (Figure 4B), we found that CAPN1, CAPN2, CAPN8, CAPN9, CAPN10, CAPN13, and CAPN15 were both higher expressed in tumor than in normal tissues and higher expressed in the high-risk calpain group than in the low risk calpain group (Figures 1A, B; Figure 4B), and CAPN5, CAPN7, and CAPNS2 were both lower expressed in tumor than in normal tissues and lower expressed in the high-risk calpain group than in the low-risk calpain group (Figures 1A, B; Figure 4B). The gene discussed is CAPN8; the disease is neoplasm.