MYC and cancer: Depending on the tissue and cellular context, all three members of the IGF2BP family selectively support expression of transcriptional master regulators of cell cycle progression and self-renewal (e.g., HOXB4, MYB, c-MYC, KRAS), and metabolic enzymes associated with normal and cancer stem cell physiology (e.g., ALDH1A1) (4, 5).