Two mouse melanoma models used in this study, Igf2bp1-KO in SM1/C57BL/6 and the doxycycline inducible Igf2bp1-KD in SW1/C3H, demonstrated the reduction of tumor’s size and the increased numbers of lymphoid and myeloid immune cells present in those tumors. The gene discussed is IGF2BP1; the disease is neoplasm.