To further investigate the physiological significance of IGF2BPs proteins in innate and adaptive immune responses in melanoma, we created Igf2bp1, 2, and 3 genes knockouts (-KO) in mouse melanoma cell line SM1 and mouse melanoma B16.F10 cells expressing T antigen (B16.F10-Tag) (Supplementary Figures 3A–D). The gene discussed is IGF2BP1; the disease is melanoma.