We demonstrated a physiological significance of SCFβ-TrCP1 E3 ubiquitin ligase’s protein substrates, β-catenin and the inhibitor of NF-kB (IKKb), for colon and melanoma cancer progression as high levels of human IGF2BP1 in these cancers were associated with NF-kB-activated antiapoptotic programs (40, 42). Here, IKBKB is linked to cancer.