IL27 and neoplasm: IL27p28 is a pleotropic growth factor—its function ranging from proliferation of cancer cells; expression of cytokines, chemokines, growth factors, and immunomodulatory molecules on cancer cells; epithelial to immune cell-like transition of cancer cells; upregulation of oncogenes and stemness genes; and increase in tumor vascularization via crosstalk with myeloid cells (69).