Interrogation of spleen as a surrogate for systemic inflammation in the state of acute infection at day 5 post-infection shows no significant change in the CD4+ T-cell population and the CD4+Foxp3+ T regulatory cells, while the number of CD11b+ myeloid cells, CD11b+F4/80+ macrophages, and CD11c+ dendritic cells significantly declined in the spleen. Here, ITGAM is linked to infection.