TIME is an important component of TME, including T lymphocytes, B lymphocytes, NK cells, macrophages and other cell subsets; these immune cells not only play a role in killing tumor cells, for example, CD8+ T cells, natural killer cells, and M1 macrophages; but also promote tumor development, for example, Th2 cells, Treg cells, and M2 macrophages (48). Here, CD8A is linked to neoplasm.