Our assessment has recognized IFITM1, SOCS3, DPYSL3, IL20RB, SLC44A4, SEMA3G, ITGA8, PCSK6, ZNF521, and DUSP1 as genes that exhibit noteworthy differential expression in association with senescence in patients with ccRCC. The gene discussed is ITGA8; the disease is nonpapillary renal cell carcinoma.