Our assessment has recognized IFITM1, SOCS3, DPYSL3, IL20RB, SLC44A4, SEMA3G, ITGA8, PCSK6, ZNF521, and DUSP1 as genes that exhibit noteworthy differential expression in association with senescence in patients with ccRCC. This evidence concerns the gene SEMA3G and nonpapillary renal cell carcinoma.