Our assessment has recognized IFITM1, SOCS3, DPYSL3, IL20RB, SLC44A4, SEMA3G, ITGA8, PCSK6, ZNF521, and DUSP1 as genes that exhibit noteworthy differential expression in association with senescence in patients with ccRCC. Here, IFITM1 is linked to nonpapillary renal cell carcinoma.