AGO2 and neoplasm: revealed that the upregulated tRF-58:75-Ala-AGC-1 interacts with the AGO2 protein to form a complex and suppress the expression of the target gene FBXO47 by directly binding to the 3’UTR of the tumor suppressor gene FBXO47, which silences the tumor suppressor effect of FBXO47 and further promotes GC cell proliferation, migration and invasion (50).