AKT1 and neoplasm: Low levels of tsRNA-1:18-tRNA-Val-AAC-1-M8 lead to low levels of PTEN as well as elevated levels of PI3K and AKT, which suggests that tsRNA-1:18-tRNA-Val-AAC-1-M8 may exert its tumor suppressor effect through the PTEN/PI3K/AKT signaling pathway (54).