The upregulated tRF-58:76-Val-TAC-1-M2 forms an RISC with the AGO2 protein, which promotes the migration and invasion of GC cells by directly binding to the 3’UTR of the tumor suppressor gene NELL2 and silencing the tumor suppressor effect of the NELL2 gene via a mechanism similar to that of miRNA-mediated target gene silencing (51). The gene discussed is NELL2; the disease is gastric cancer.