tRF-1:24-chrM.Gln-TTG can function as a miRNA-like fragment, bind to the AGO2 protein, and directly silence the expression of GPR78, a member of the G-protein-coupled receptor superfamily, by complementing the 3’UTR of GPR78 mRNA, thereby inhibiting the proliferation, invasion and metastasis of GC cells and promoting their apoptosis (55). This evidence concerns the gene GPR78 and gastric cancer.