Some of the known small molecule modulators of clock proteins in gastric cancer therapeutics are REV-ERBαagonists “GSK4112 (SR6452) and berberine”, RORα/γ agonist “Nobiletin”, CK1α/δ/ε inhibitor “IC261”, and CK2 inhibitor “TBB and CX-4945 (Silmitasertib) (48). Here, CLOCK is linked to gastric cancer.