To determine the impact of pharmacological inhibition of ferroptosis on Mcu+/+ and Mcu−/− MC38 tumor growth, we i.p. injected a tolerable dose of liproxstatin-1 into implanted MC38 tumor bearing mice, liproxstatin-1 did not significantly affect the Mcu+/+ MC38 tumor development, but restored tumor development in Mcu−/− MC38 tumors (Fig. 4m). The gene discussed is MCU; the disease is neoplasm.