Gpx4−/−-Gpx4-K90R MC38 tumor bearing mice exhibited a significant delay in tumor growth as shown in volume and weight compared with Gpx4−/−-Gpx4-WT tumors, while Gpx4−/−-Gpx4-K90R/D23N MC38 tumor bearing mice showed similar tumor development with Gpx4−/−-Gpx4-WT tumors (Fig. 5a). Here, GPX4 is linked to neoplasm.