MCU and neoplasm: However, we found a significant delay in tumor growth as shown in tumor volume and tumor weight in C57BL/6 mice implanted with Mcu−/− MC38 tumors (Fig 4b), Mcu−/− LLC tumors (Extended Data Fig. 6b) and Mcu−/− B16-OVA tumors (Extended Data Fig. 6k), respectively, compared with Mcu+/+ tumors in vivo.