These two regions are likely to exert the effects of T2D risk variants on SLC30A8 and nearby gene expression, and contain β-cell specific transcription factor binding from FOXA2 and NKX2.2 (for R1) or PDX1 (for R2) (Figure S3B) (http://pasqualilab.upf.edu/app/isletregulome) [32]. This evidence concerns the gene SLC30A8 and type 2 diabetes mellitus.