The stressors used, OAβ 42, a precursor to AD plaques that damages neurons by itself36, and erastin to set ferroptosis in motion, limiting the uptake of cystine, consuming GSH, and inhibiting the cystine/glutamate antiporter system (System Xc−) and glutathione peroxidase 4 (GPX4)37. The gene discussed is GPX4; the disease is Alzheimer disease.