<h4>Background</h4>Autoantibodies against the vesicular glutamate transporter type 2 (VGlut2) can trigger impaired synaptic signaling and are described here for the first time in association with mixed dementia.<h4>Methods</h4>We report on a 71-year-old female patient with a dementing syndrome who underwent a thorough dementia diagnosis including neuropsychological testing, magnetic resonance imaging (MRI), <sup>18</sup>F-fluorodesoxyglucose positron emission tomography (FDG-PET), and a spinal tap to search for neural autoantibodies.<h4>Results</h4>Our patient exhibited mixed dementia. The gene discussed is SLC17A6; the disease is dementia.