Neuroinflammation is an important player upstream of tissue degeneration in RP (Ortega and Jastrzebska, 2021); prominently represented by neuroinflammatory pathways from PD, emphasizing a potential link of PD-related alpha-synuclein to RP (D’Alessandro et al., 2022); kynurenine pathway upstream of prostaglandin synthesis links RP to COVID-19. The gene discussed is SNCA; the disease is COVID-19.