We found that senescent markers such as CDKN1A,28, 29CDKN2A,29, 30CBX730, 31 and SIRT130 were highly expressed in cluster 2 and cluster 3, and this result was consistent in the TCGA‐CRC cohort (Figure 2F and Figure S2C).Overall, we identified three distinct senescence subtypes with varying activation levels of senescent and cancer hallmark pathways, as well as prognosis based on survival analysis. This evidence concerns the gene CDKN1A and cancer.