The gene expressions of CD274(PD‐L1), PDCD1(PD‐1), CTLA4, and LAG3 were higher in cluster 2, while myeloid‐derived suppressor cells (MDSC), cancer‐associated fibroblasts (CAFs), EMT, T cell exhaustion and other immune suppression/exclusion/exhaustion related signatures were most expressed in cluster 3 (Figure 4C). The gene discussed is CTLA4; the disease is cancer.