CDH1 and infectious otitis media: In contrast, ARC1, ARC31, and ARC111 have shown a negative correlation with sulfate and calcium (Spearman, R < −0.3, p < 0.05) but a positive correlation with silicate and phosphate (Spearman, R > 0.3, p < 0.05), indicating their prevalence in methane and correlation with AOM (Figure 4A).