Contrarily, PPARGC1A expression has been found to be downregulated in HCC, and in vitro and in vivo tests have demonstrated that upregulation of PPARGC1A can successfully prevent HCC cell invasion and migration by blocking the Wnt/−catenin/PDK1 axis and thereby inhibiting aerobic glycolysis (71). Here, PDK1 is linked to hepatocellular carcinoma.