Previously, we studied some secondary metabolites and observed their effects on SENP1 protein in various cancer cell lines and nervous system cells (Amiraslani et al., 2012; Alemi et al., 2013; Esmaeilzadeh et al., 2013; Rashid et al., 2019; Ahmadi et al., 2020; Taghvaei et al., 2021b; Taghvaei et al., 2021c). The gene discussed is SENP1; the disease is cancer.