MAPT and Alzheimer disease: It has been found that restoring miR-23b-3p levels via direct delivery of AAV-loaded miR-23b-3p into the brain or miR-23b-3p synthetic mimics transfected into neuronal cells both suppressed Aβ1-42 levels and tau phosphorylation against AD-related deficits, thereby inhibiting cell apoptosis (Jiang et al., 2022; Liu et al., 2022).