Downregulation of miR-23b-3p has been reported with disease development in various AD models, including in the hippocampus and cortex of amyloid precursor protein (APP)/presenilin 1 (PS1) mice and senescence-accelerated mouse prone 8 (SAMP8) mice at different ages (Liu et al., 2020). This evidence concerns the gene PSEN1 and Alzheimer disease.