Genetic defects in the SLC1A4 gene (MIM: 600229) have been linked to an autosomal recessive neurodevelopmental disorder (MIM: 616657) that is mainly characterized by early infantile onset of spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM) leading to severe and progressive early developmental delay (6). This evidence concerns the gene SLC1A4 and microcephaly.