In support of this, sGC stimulation by BAY 41-2272 has been shown to decrease ventricular interstitial fibrosis and collagen accumulation in a hypertensive rat model (23), while the sGC activator, ataciguat, attenuated extracellular matrix accumulation in the non-infarcted ventricle of rats with heart failure and myocardial infarction (24). This evidence concerns the gene SGCB and heart failure.