Notably, tolerance to sepsis-promoting bacteria could be affected by complementary actions of hepatocyte Nrf1 and Nrf2, as this has been strongly linked to HDL functionality and the hepatic acute phase response (Carpentier and Scruel, 2002; Haas and Mooradian, 2010; Strnad et al., 2017; Kubes and Jenne, 2018; Laudanski, 2021). The gene discussed is NRF1; the disease is Sepsis.