Since constipation is a common symptom of gastrointestinal diseases, exploring the GFs related to constipation can provide evidence for the role of various GFs in the pathogenesis of other gastrointestinal diseases, such as TGF-β and HB-EFG in IBS, and FGF7 in intestinal epithelial cell hyperproliferation. The gene discussed is TGFB1; the disease is gastrointestinal disease.