Since the incidence and prevalence of type 1 diabetes are increasing worldwide (7, 8), and this is accompanied by underlying changes in sociodemographic factors (for instance the continuous increase in maternal age and more frequent occurrence of births at earlier gestations) (9, 10) and the use of novel insulins, insulin delivery devices, and continuous glucose measurement devices, these changes may in turn also affect the trends of pregnancy outcomes in this subpopulation. Here, INS is linked to type 1 diabetes mellitus.