On the other hand, the inactivation of STAT3/NF-κB can pin down the overexpression of several kinases such as janus kinase 1/2 (JAK1/2), TGF-β-activated kinase 1 (TAK1), c-Src, and inhibitor of Iκβ kinase (IKK) in HNSCC cells and garcinol was successfully reported to hinder the growth in an athymic nu/nu mice. The gene discussed is JAK1; the disease is head and neck squamous cell carcinoma.