FOS and neoplasm: JUNB, a member of the Fos/Jun family, is a key component of activator protein transcription factors and a major target element of mitotic activation and transmission pathways.28Previous studies have found that JUNB negatively regulated cell proliferation and Ras-mediated malignant transformation while also participating in proapoptotic pathways.29, 30, 31, 32Guo et al found that the positive expression values of JUNB in tumor tissue and normal tissue were 20.00 and 76.32%, respectively.