In recent years, accumulating evidence has shown that NR4A1 (Nur77) and other family members NR4A2 (Nurr1) and NR4A3 (Nor1) are critically involved in maintaining intracellular environmental stability and pathophysiology.42NR4A1 has been confirmed to be an oncogene in solid tumor in vivo studies,43, 44, 45but it appears to have the opposite prognostic profile in HCC. The gene discussed is NR4A3; the disease is hepatocellular carcinoma.