A recent study reported that “RNAP II subunit 3 (RPB3)” can promote the proliferation of HCC through targeted regulation of “vesicular, overexpressed in cancer, prosurvival protein 1 (VOPP1).”15In addition, in the present study, we found that RNAP II may be regulated by cyclin-dependent kinase (CDK) and cyclins to affect the occurrence and development of HCC. The gene discussed is VOPP1; the disease is hepatocellular carcinoma.