The chronic inflammatory state of HCC is not only one of the important components of its complex tumor microenvironment, but it also affects the biological behavior of its metastasis and malignant prognosis.19Both TNF-α and IL-17 signaling pathways are canonical inflammatory pathways, and the results of several previous studies have evidenced their close connection with HCC.20, 21Recent research has revealed the unique roles of these pathways in the progression of NAFLD to HCC. The gene discussed is IL17A; the disease is neoplasm.