The dysfunctional p53 and low-expressed JUNB could synergistically downregulate the expression of the metastasis suppressor KAI1 in HCC, thereby affecting the survival prognosis of HCC patients.33Another study by Guo et al revealed that the fusion gene of wtp53 and JunB not only inhibited the growth of liver cancer cells and promoted tumor cell apoptosis, but also suppressed the invasive ability of tumor cells by upregulating the expression of KAI1.34FOSB is a member of the Fos gene family, which also includes FOS, FOSL1, and FOSL2. The gene discussed is FOSL1; the disease is hepatocellular carcinoma.