Studies have found that NR4A1 can regulate the expression of adipogenesis-related genes, thereby suppressing adipocyte differentiation and adipogenesis.48In a high fat diet-fed mouse model, the knockout of NR4A1 aggravated insulin resistance and hepatic steatosis, whereas the overexpression of NR4A1 reduced hepatic triglyceride accumulation.49 The gene discussed is NR4A1; the disease is Insulin resistance.