Additionally, Zhong et al found that THZ1, an inhibitor of CDK7, induced apoptosis and inhibited the proliferation of liver cancer cells by reducing RNAPII-CTD phosphorylation, inducing p53 expression, and inhibiting anti-apoptotic gene expression.16Therefore, RNAPII and cell cycle-related factors may play an important unknown role in the progression of NAFLD to HCC, which needs to be confirmed. The gene discussed is TP53; the disease is metabolic dysfunction-associated steatotic liver disease.