CTLA4 and cancer: In this study, we compared the differences in immune infiltration between the high-score group and low-score group of the constructed model, explored the correlation between PANoptotic score and the expression of several major immune checkpoints, and extended the model to the pan-cancer level by analyzing the correlation between PANoptic score and immune checkpoints CD274, CTLA-4 and LAG3 in some other tumors.