NLRP3 had the highest mutation frequency, and the mutation frequency of NLRP3, NLRP1, CASP1, and NLRP9 were all greater than 0.5%, and the most common type of mutation was missense mutation, but we did not observe any mutation of FADD. In addition, we studied the copy number variation of PANoptosome-related genes in glioma (Figure 1C). This evidence concerns the gene NLRP9 and central nervous system cancer.