In this study, based on PANoptosis, which is characterized by the crosstalk between the pyroptosis, apoptosis, and necroptosis of different cell death pathways (Jiang et al., 2021; Liu et al. J. 2022), we focused on the components of the PANoptosome, a protein complex that activates this cell death pathway and included 17 genes including AIM2, CASP8, NLRP3, NLRP1, ZBP1, etc. We found widespread alterations in the expression of the above genes in glioma patients obtained from the database and clustered patients according to 17 genes’ differential expression. The gene discussed is CASP8; the disease is central nervous system cancer.