MED12 and microphthalmia: In fetal extremity anomalies, overlapping fingers/clinodactyly with or without clenched hand is remarkable in early (12–13 weeks) gestation screening (Bronshtein et al., 1995), which makes it a more favorable indicator than facial deformities such as microphthalmia or microretrognathia in fetuses with MED12 deficiency (Caro-Llopis et al., 2016; Amodeo et al., 2020).