KIF1A and HMGA2 were some of the top upregulated genes in aggressive tumors, the first one has been associated with drug resistance in breast cancer (60, 61) and the latter was reported to be associated with reduced overall survival in patients with LUAD, positively regulating lung cancer proliferation, progression, and metastasis (62, 63). The gene discussed is KIF1A; the disease is breast carcinoma.