As such, future studies should focus on the characterization of EV miRNA profiles from distinct ATM subpopulations, the study of EV and miRNA heterogeneity within a single ATM secretome, and ultimately the integration of multiple miRNA effects at early and late timepoints in the obesity progression to identify key determinants of the overall ATM functional program. This evidence concerns the gene ATM and obesity due to melanocortin 4 receptor deficiency.