HAVCR2 and neoplasm: Severson et al. found that T cells in the metastatic LNs of patients with DTC exhibited different degrees of exhausted phenotype, demonstrated as upregulated expression of programmed cell death (PD‐1), T‐cell immunoglobulin, and mucin domain‐containing protein 3 (TIM‐3), and CD69; reduced secretion of TNF‐α and IFN‐γ; and weakened cytotoxicity of tumor cells.13