In addition, the blocking of IL-6 in the supernatant of the co-culture of NK-92 cells and HCC SK-Hep1 cells downregulated the expression of NKp30 and CD94 receptors on the surface of NK-92 cells (Fig. 3, NKp30+; non-treated 67.82%, anti-IL-6 51.96%, CD94+; non-treated 81.91%, anti-IL-6 72.46%, *p < 0.05). Here, IL6 is linked to hepatocellular carcinoma.