This may be a direct effect of IL-2, as there have been reports of IL-2 induced upregulation of MHC class II in neutrophils and of MHC class I in papillary thyroid cancer cells [38, 39], but at the same time monocyte-derived DCs were found to neither express IL-2Rβ nor respond to IL-2 [40]. This evidence concerns the gene IL2RB and thyroid gland papillary carcinoma.