We have previously investigated LOAd703 (delolimogene mupadenorepvec), expressing trimerized membrane-bound (TMZ)-CD40L and 4-1BBL, extensively in pancreatic cancer, multiple myeloma, and in combination with chimeric antigen receptor T cells in B-cell lymphoma and with checkpoint blockade in melanoma [3–7]. Here, CD40LG is linked to melanoma.