MiR-632 activated Wnt/β-catenin to promote full-thickness skin wound healing in rats.<h4>Conclusions</h4>OA-RD17 exhibited promising therapeutic effects on mice (full-thickness, deep second-degree burns), and ex vivo skin wounds in diabetic patients by regulating macrophages proliferation, migration, and polarization (MAPK, NF-κB), and keratinocytes proliferation and migration (TLR4/MAPK/miR-632/Wnt/β-catenin molecular axis). The gene discussed is TLR4; the disease is diabetes mellitus.